Emergence of preferred firing sequences in large spiking neural networks during simulated neuronal development.
Int J Neural Syst
; 18(4): 267-77, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18763727
ABSTRACT
Two main processes concurrently refine the nervous system over the course of development cell death and selective synaptic pruning. We simulated large spiking neural networks (100 x 100 neurons "at birth") characterized by an early developmental phase with cell death due to excessive firing rate, followed by the onset of spike timing dependent synaptic plasticity (STDP), driven by spatiotemporal patterns of stimulation. The cell death affected the inhibitory units more than the excitatory units during the early developmental phase. The network activity showed the appearance of recurrent spatiotemporal firing patterns along the STDP phase, thus suggesting the emergence of cell assemblies from the initially randomly connected networks. Some of these patterns were detected throughout the simulation despite the activity-driven network modifications while others disappeared.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Simulação por Computador
/
Potenciais de Ação
/
Córtex Cerebral
/
Redes Neurais de Computação
/
Rede Nervosa
/
Neurônios
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Neural Syst
Assunto da revista:
ENGENHARIA BIOMEDICA
/
INFORMATICA MEDICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
França