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Epidemiological aspects of hepatitis C virus infection among renal transplant recipients in Central Brazil.
Botelho, Sílvia M; Ferreira, Renata C; Reis, Nádia R S; Kozlowski, Aline G; Carneiro, Megmar A S; Teles, Sheila A; Yoshida, Clara F T; Martins, Regina M B.
Afiliação
  • Botelho SM; Instituto de Patologia Tropical e Saúde Pública Faculdade de Enfermagem, Universidade Federal de Goiás, Goiânia, Brasil.
Mem Inst Oswaldo Cruz ; 103(5): 472-6, 2008 Aug.
Article em En | MEDLINE | ID: mdl-18797761
An investigation was conducted involving 255 renal transplant recipients in the state of Goiás, Central Brazil, to determine the prevalence of hepatitis C virus (HCV), its risk factors, the genotypes involved, and the level of alanine aminotransferase (ALT) present in the patients. All serum samples were tested for anti-HCV antibodies and HCV RNA. Forty-one patients were anti-HCV and/or HCV RNA positive, resulting in an overall HCV infection prevalence of 16.1% (95% CI: 11.9-21.3). A multivariate analysis of risk factors showed that a history of blood transfusions without anti-HCV screening, the length of time spent on hemodialysis, and renal transplantation before 1994 are all associated with HCV positivity. In HCV-positive patients, only 12.2% had ALT levels above normal. Twenty-eight samples were genotyped as genotype 1, subtypes 1a (62.5%) and 1b (31.3%), and two samples (6.2%) were genotype 3, subtype 3a. These data show a high prevalence of HCV infection and low ALT levels in the studied population. The risk factor analysis findings emphasize the importance of public health strategies such as anti-HCV screening of candidate blood and organ donors, in addition to the stricter adoption of hemodialysis-specific infection control measures. The present study also demonstrates that HCV genotype 1 (subtype 1a) is predominant in this population.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Rim / Hepatite C / Hepacivirus / Anticorpos Anti-Hepatite C Tipo de estudo: Diagnostic_studies / Etiology_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Mem Inst Oswaldo Cruz Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Rim / Hepatite C / Hepacivirus / Anticorpos Anti-Hepatite C Tipo de estudo: Diagnostic_studies / Etiology_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Mem Inst Oswaldo Cruz Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil