[Immunomorphological characteristics of pulmonary langerhans cell histiocytosis].
Arkh Patol
; 70(4): 3-5, 2008.
Article
em Ru
| MEDLINE
| ID: mdl-18807516
ABSTRACT
Lung tissue specimens, obtained during lung biopsy or resection, were morphologically and immunohistochemically studied in 27 patients with Langerhans cell (LC) histiocytosis (LCH). The latter was diagnosed on the basis of the expression of CD1a and S-100. Without immunophenotyping, its diagnosis was difficult due to impaired tissue architectonics (sclerosis, bullous transformation) and artifacts that were inevitably present during lung biopsy. LCs in the infiltrates were shown to be capable for apoptosis. Induction of LC apoptosis may be regarded as a therapeutic strategy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas S100
/
Histiocitose de Células de Langerhans
/
Apoptose
/
Antígenos CD1
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Ru
Revista:
Arkh Patol
Ano de publicação:
2008
Tipo de documento:
Article