The bacterial superantigen and superantigen-like proteins.
Immunol Rev
; 225: 226-43, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18837785
ABSTRACT
SUMMARY:
The bacterial superantigens are protein toxins that bind to major histocompatibility complex class II and T-cell receptor to stimulate large numbers of T cells. The majority are produced by the Gram-positive organisms Staphylococcus aureus and Streptococcus pyogenes and are the causative agents in toxic shock syndrome, an acute disease caused by the sudden and massive release of T-cell cytokines into the blood stream. The structure and function of the superantigens has revealed a common architecture that is also shared by another group of staphylococcal virulence factors called the superantigen-like proteins (SSL). Together, this family of structurally related molecules highlights how a common pathogenic organism has employed a simple but adaptable protein to generate an armamentarium of potent defense molecules designed to target of the innate and adaptive immune response.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Choque Séptico
/
Staphylococcus aureus
/
Streptococcus pyogenes
/
Receptores de Antígenos de Linfócitos T
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Linfócitos T
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Superantígenos
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Immunol Rev
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Nova Zelândia