Silent synapses and the emergence of a postsynaptic mechanism for LTP.
Nat Rev Neurosci
; 9(11): 813-25, 2008 Nov.
Article
em En
| MEDLINE
| ID: mdl-18854855
ABSTRACT
Silent synapses abound in the young brain, representing an early step in the pathway of experience-dependent synaptic development. Discovered amidst the debate over whether long-term potentiation reflects a presynaptic or a postsynaptic modification, silent synapses--which in the hippocampal CA1 subfield are characterized by the presence of NMDA receptors but not AMPA receptors--have stirred some mechanistic controversy of their own. Out of this literature has emerged a model for synapse unsilencing that highlights the central role for postsynaptic AMPA-receptor trafficking in the expression of excitatory synaptic plasticity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Potenciação de Longa Duração
/
Potenciais Pós-Sinápticos Excitadores
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos