The expression of vascular endothelial growth factor and its receptors in port-wine stains.
Otolaryngol Head Neck Surg
; 139(4): 560-4, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18922344
ABSTRACT
OBJECTIVE:
To investigate the expression of vascular endothelial growth factor (VEGF) and its receptor (VEGF-R2) in port-wine stains (PWSs).DESIGN:
An immunohistochemistry (IHC) study on formalin-fixed, paraffin-embedded specimens.METHODS:
Representative sections from surgical resection specimens of 12 PWS patients and 12 control specimens stained with routine IHC by using polyclonal anti-VEGF and anti-VEGF-R2 antibodies. Slides were evaluated semiquantitatively for the intensity of staining for VEGF and VEGF-R2 by using a scoring system varying from 0 to 3+.RESULTS:
PWS specimens showed statistically significant overexpression of both VEGF and VEGF-R2 molecules when compared with control specimens (P < 0.005).CONCLUSIONS:
VEGF and its receptor may play an important role in the pathogenesis of PWS. It is possible that PWS may progress by hyperplasia in addition to hypertrophy. VEGF-R blockade may have a potential role as a targeted approach in the treatment of this disfiguring condition in the future.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Mancha Vinho do Porto
/
Receptores de Fatores de Crescimento do Endotélio Vascular
/
Fator A de Crescimento do Endotélio Vascular
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Otolaryngol Head Neck Surg
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos