Novelty determines the effects of olfactory enrichment on memory and neurogenesis through noradrenergic mechanisms.
Neuropsychopharmacology
; 34(3): 786-95, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-18946468
ABSTRACT
Commonly used experimental paradigms of environmental enrichment combine increased social interactions and sensory inputs and renewal of the objects present in the environment. However, the specific contribution of novelty to the effects of enrichment is unclear. Here, we show that repeated daily exposure to single novel odorants and not to an enriched but stable olfactory environment improves short-term olfactory memory and neurogenesis in the mouse olfactory bulb. In addition, these positive effects are mediated by noradrenalin as they are blocked by a noradrenergic receptor antagonist. These data suggest that novelty recognition and noradrenergic mechanisms are crucial in mediating neural plasticity induced by olfactory enrichment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Norepinefrina
/
Comportamento Exploratório
/
Percepção Olfatória
/
Neurogênese
/
Memória de Curto Prazo
Limite:
Animals
Idioma:
En
Revista:
Neuropsychopharmacology
Assunto da revista:
NEUROLOGIA
/
PSICOFARMACOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
França