The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.
Drug Metab Rev
; 40(4): 553-624, 2008.
Article
em En
| MEDLINE
| ID: mdl-18949601
ABSTRACT
The aldo-keto reductase (AKR) superfamily comprises enzymes that catalyze redox transformations involved in biosynthesis, intermediary metabolism, and detoxification. Substrates of AKRs include glucose, steroids, glycosylation end-products, lipid peroxidation products, and environmental pollutants. These proteins adopt a (beta/alpha)(8) barrel structural motif interrupted by a number of extraneous loops and helixes that vary between proteins and bring structural identity to individual families. The human AKR family differs from the rodent families. Due to their broad substrate specificity, AKRs play an important role in the phase II detoxification of a large number of pharmaceuticals, drugs, and xenobiotics.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
/
Oxirredutases do Álcool
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Metab Rev
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos