Preoperative chemoradiation for locally advanced rectal cancer with capecitabine 2,000 mg/m2/day.
J Med Assoc Thai
; 91(10): 1583-8, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18972903
ABSTRACT
OBJECTIVE:
Evaluate the efficacy and the tolerability of preoperative chemoradiation with high dose Capecitabine. MATERIAL ANDMETHOD:
Fifteen patients with locally advanced resectable rectal cancer were treated with Capecitabine 2,000 mg/m2/day, orally 7 days/week concurrent with whole pelvic irradiation 45 Gy in 25 fractions/5 weeks. Patients underwent surgery in the following 4-6 weeks.RESULTS:
After complete treatment, 11 patients (73%) underwent surgery. Ten patients (66%) had sphincter preservative surgery; three of them had primary tumors located in the lower rectum. Five patients had grade 2 and one patient had grade 3 diarrhea. No grade 4 toxicity was reported.CONCLUSION:
Preoperative Capecitabine 2,000 mg/m2/day concurrent with whole pelvic irradiation were effective and well tolerated The potential dose limiting toxicity effect was the diarrhea.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cuidados Pré-Operatórios
/
Neoplasias Colorretais
/
Desoxicitidina
/
Fluoruracila
/
Antimetabólitos Antineoplásicos
Limite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Med Assoc Thai
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Tailândia