[Confirmation of the use of skin biopsy in small-fiber neuropathy. First results]. / Confirmation de l'intérêt de la biopsie cutanée dans la neuropathie des petites fibres. Résultats préliminaires.
Rev Neurol (Paris)
; 165(3): 249-55, 2009 Mar.
Article
em Fr
| MEDLINE
| ID: mdl-19056097
ABSTRACT
INTRODUCTION:
In small-fiber neuropathy, skin biopsy reveals a reduction of intraepidermal nerve fiber density (IENFD), a feature often necessary for diagnosis. In France, this technique has not been widely used for this purpose. PATIENT ANDMETHOD:
To validate this method, we studied 13 patients with suspected small-fiber neuropathy, analyzed their nervous intra- and subepidermal network with a punch skin biopsy and compared our data with those of literature.RESULTS:
Ten patients had pure small-fiber neuropathy and three an axonal polyneuropathy involving large-caliber nerve fibers. In the group of patients with pure small-fiber neuropathy, we found medium IENFD (11.6 +/- 4.46 fibers per millimeter in the proximal thigh and 7.15 +/- 3.59 fibers per millimeter in distal leg), well correlated with the electron microscopy quantitative and qualitative analysis of the unmyelinated subepidermal fibers.CONCLUSION:
This work demonstrated the good reproducibility of skin biopsy for analyzing the small-fibers in our cohort. These results require further confirmation in a larger cohort and validation in comparison with controls analyzed on a local level. Nevertheless, these techniques seem to be useful to assess the difficult diagnosis of small-fiber neuropathy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Doenças do Sistema Nervoso Periférico
/
Fibras Nervosas
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Fr
Revista:
Rev Neurol (Paris)
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
França