[Study on T cell subsets in HIV/AIDS patients].

ABSTRACT

OBJECTIVE: Analyze Naive and Mermory T cell subsets in HIV/AIDS patients and investigate their relationship with disease development. METHODS: T cell subsets from 15 normal control subjects, 79 HIV/ AIDS patients were detected by FCM. RESULTS: With diesase progression, CD4+ Naive cell counts and ratio was both decreased obviously (P < 0.001); CD4+ Tcm cell counts was significantly decreased (P < 0.001), CD4+ Tcm cell ratio was obviously higher (P = 0.002); CD4 TEM cell ratio was obviously increased( P < 0.001); CD8+ T Naive cell counts and ratio was also decreased obviously (P < 0.05); CD8+ T(CM), T(EM), T(EMRA) are not significantly different. CONCLUSIONS: The peripheral lymphocyte subsets in HIV/AIDS patients changed obviously. The counts of naive T cell decreased, while the proportion of memory T cell increased significantly. It will help to understand pathogenesis of HIV.