Amyloid beta concentrations in older people with Down syndrome and dementia.
Neurosci Lett
; 451(2): 162-4, 2009 Feb 20.
Article
em En
| MEDLINE
| ID: mdl-19111900
People with Down syndrome develop Alzheimer's disease with an early age of onset. Plasma amyloid beta (Abeta) levels were measured in individuals with Down syndrome who were over the age of 40. No associations between age and Abeta1-40 and Abeta1-42 concentrations were found and nor were Abeta1-40 and Abeta1-42 levels found to vary between those with Alzheimer's-type dementia and those without dementia. The APOE genotype was not found to have an impact upon Abeta1-40 or Abeta1-42 concentrations. These data suggest that other factors play important roles in determining the onset and progression of dementia in the Down syndrome population.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Peptídeos beta-Amiloides
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Síndrome de Down
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Doença de Alzheimer
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2009
Tipo de documento:
Article