Bronchopulmonary disposition of micafungin in healthy adult volunteers.
Antimicrob Agents Chemother
; 53(3): 1218-20, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19114675
ABSTRACT
By way of bronchoscopy and bronchoalveolar lavage, intrapulmonary steady-state concentrations of micafungin administered at 150 mg daily to 15 healthy volunteers were determined at 4, 12, and 24 h after the third dose. The micafungin disposition was predominantly intracellular, with approximately 106% penetration into alveolar macrophages and 5% penetration into epithelial lining fluid.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Brônquios
/
Equinocandinas
/
Lipopeptídeos
/
Pulmão
/
Antifúngicos
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos