T-type calcium channels regulate cortical plasticity in-vivo. [corrected].
Neuroreport
; 20(3): 257-62, 2009 Feb 18.
Article
em En
| MEDLINE
| ID: mdl-19212242
ABSTRACT
T-type voltage-dependent calcium channels may play an important role in synaptic plasticity, but lack of specific antagonists has hampered investigation into this possible function. We investigated the role of the T-type channel in a canonical model of in-vivo cortical plasticity triggered by monocular deprivation. We identified a compound (TTA-I1) with subnanomolar potency in standard voltage clamp assays and high selectivity for the T-type channel. When infused intracortically, TTA-I1 reduced cortical plasticity triggered by monocular deprivation while preserving normal visual response properties. These results show that the T-type calcium channel plays a central role in cortical plasticity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Visual
/
Percepção Visual
/
Visão Monocular
/
Canais de Cálcio Tipo T
/
Dominância Ocular
/
Plasticidade Neuronal
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neuroreport
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos