DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination.
Adv Immunol
; 101: 163-89, 2009.
Article
em En
| MEDLINE
| ID: mdl-19231595
ABSTRACT
As part of the adaptive immune response, B cells alter their functional immunoglobulin (Ig) receptor genes through somatic hypermutation (SHM) and/or class switch recombination (CSR) via processes that are initiated by activation induced cytidine deaminase (AID). These genetic modifications are targeted at specific sequences known as Variable (V) and Switch (S) regions. Here, we analyze and review the properties and function of AID target sequences across species and compare them with non-Ig sequences, including known translocation hotspots. We describe properties of the S sequences, and discuss species and isotypic differences among S regions. Common properties of SHM and CSR target sequences suggest that evolution of S regions might involve the duplication and selection of SHM hotspots.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulinas
/
Genes de Imunoglobulinas
/
Linfócitos B
/
Switching de Imunoglobulina
/
Citidina Desaminase
/
Hipermutação Somática de Imunoglobulina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Adv Immunol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos