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Origins and Mechanisms of miRNAs and siRNAs.
Carthew, Richard W; Sontheimer, Erik J.
Afiliação
  • Carthew RW; Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208-3500, USA. r-carthew@northwestern.edu
Cell ; 136(4): 642-55, 2009 Feb 20.
Article em En | MEDLINE | ID: mdl-19239886
Over the last decade, approximately 20-30 nucleotide RNA molecules have emerged as critical regulators in the expression and function of eukaryotic genomes. Two primary categories of these small RNAs--short interfering RNAs (siRNAs) and microRNAs (miRNAs)--act in both somatic and germline lineages in a broad range of eukaryotic species to regulate endogenous genes and to defend the genome from invasive nucleic acids. Recent advances have revealed unexpected diversity in their biogenesis pathways and the regulatory mechanisms that they access. Our understanding of siRNA- and miRNA-based regulation has direct implications for fundamental biology as well as disease etiology and treatment.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / RNA Interferente Pequeno Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / RNA Interferente Pequeno Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Estados Unidos