Large-scale and automated DNA sequence determination.
Science
; 254(5028): 59-67, 1991 Oct 04.
Article
em En
| MEDLINE
| ID: mdl-1925562
ABSTRACT
DNA sequence analysis is a multistage process that includes the preparation of DNA, its fragmentation and base analysis, and the interpretation of the resulting sequence information. New technological advances have led to the automation of certain steps in this process and have raised the possibility of large-scale DNA sequencing efforts in the near future [for example, 1 million base pairs (Mb) per year]. New sequencing methodologies, fully automated instrumentation, and improvements in sequencing-related computational resources may render genome-size sequencing projects (100 Mb or larger) feasible during the next 5 to 10 years.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Sequência de Bases
/
Projeto Genoma Humano
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1991
Tipo de documento:
Article