Defining protective responses to pathogens: cytokine profiles in leprosy lesions.
Science
; 254(5029): 277-9, 1991 Oct 11.
Article
em En
| MEDLINE
| ID: mdl-1925582
ABSTRACT
The immunological mechanisms required to engender resistance have been defined in few infectious diseases of man, and the role of specific cytokines is unclear. Leprosy presents clinically as a spectrum in which resistance correlates with cell-mediated immunity to the pathogen. To assess in situ cytokine patterns, messenger RNA extracted from leprosy skin biopsy specimens was amplified by the polymerase chain reaction with 14 cytokine-specific primers. In lesions of the resistant form of the disease, messenger RNAs coding for interleukin-2 and interferon-gamma were most evident. In contrast, messenger RNAs for interleukin-4, interleukin-5, and interleukin-10 predominated in the multibacillary form. Thus, resistance and susceptibility were correlated with distinct patterns of cytokine production.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citocinas
/
Hanseníase
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1991
Tipo de documento:
Article