Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression.
Nat Methods
; 6(4): 271-3, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19270699
ABSTRACT
Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Dessensibilização Imunológica
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Transplante de Células-Tronco
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Sobrevivência de Enxerto
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Neurônios
Limite:
Animals
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Humans
Idioma:
En
Revista:
Nat Methods
Assunto da revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Reino Unido