Association of HLA-A in autoimmune myasthenia gravis with thymoma.
J Neuroimmunol
; 210(1-2): 120-3, 2009 May 29.
Article
em En
| MEDLINE
| ID: mdl-19278738
ABSTRACT
We investigated an association of the HLA-A locus in 78 French Caucasian patients with autoimmune myasthenia gravis (MG) and thymic epithelial tumours. The largest effect was a protection associated with HLA-A02 in MG patients with a B2 type thymoma (OR=0.323, 95% CI 0.113-0.756, P=0.00041). The frequency of HLA-A25 was also increased in the whole group of patients (OR=3.62, 95% CI 1.62-7.08, P=0.0041). Our findings emphasise the interest of the histological classification in the genetic study of thymomas.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timoma
/
Antígenos HLA-A
/
Predisposição Genética para Doença
/
Miastenia Gravis
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
França