Strong correlations of anti-viral capsid antigen antibody levels in first-degree relatives from families with Epstein-Barr virus-related lymphomas.
J Infect Dis
; 199(8): 1121-7, 2009 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-19284285
ABSTRACT
BACKGROUND:
Markers of Epstein-Barr virus (EBV) infection include anti-viral capsid antigen (VCA) immunoglobulin (Ig) G. High anti-VCA titers are associated with EBV-related lymphoproliferation, such as Burkitt lymphoma (BL) and Hodgkin lymphoma (HL).METHODS:
Intrafamilial correlations of anti-VCA IgG levels were studied in 3 settings 127 families recruited through patients with HL in France (population A), 31 families recruited through patients with BL in Uganda (population B), and 74 large families from a general population in Cameroon (population C). Titers were determined by enzyme-linked immunosorbent assay (populations A and C) or by immunofluorescence analysis (population B).RESULTS:
In populations A and B, the anti-VCA IgG titers of the relatives of patients with HL or BL increased significantly (P = .01 and P < .001, respectively) with those of the index case patient. In all 3 populations, anti-VCA IgG titers were significantly correlated (P < .001 for A, P = .002 for B, and P < .001 for C) between genetically related individuals (father-offspring, mother-offspring, and sibling-sibling) but not between spouses. Similar results were obtained for population A after adjustment for total IgG levels. In all cases, the pattern of correlations was consistent with a polygenic model, with heritability ranging from 0.32 to 0.48.CONCLUSION:
These results provide evidence for the genetic control of anti-VCA IgG titers and pave the way for identification of the loci involved.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Hodgkin
/
Linfoma de Burkitt
/
Herpesvirus Humano 4
/
Proteínas do Capsídeo
/
Anticorpos Antivirais
/
Antígenos Virais
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Africa
/
Europa
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
França