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Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model.
Sun, Bo; Roh, Kyoung-Hwan; Park, Jeong-Ran; Lee, Sae-Rom; Park, Sang-Bum; Jung, Ji-Won; Kang, Soo-Kyung; Lee, Yong-Soon; Kang, Kyung-Sun.
Afiliação
  • Sun B; Zoonotic Disease Institute, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
Cytotherapy ; 11(3): 289-98, 1 p following 298, 2009.
Article em En | MEDLINE | ID: mdl-19308770
ABSTRACT
BACKGROUND

AIMS:

Mesenchymal stromal cells (MSC) have been studied intensively in regenerative medicine. However, their therapeutic potential against tumor formation and cancer metastasis is still unclear. The effects of transplantation of MSCs in early-stage of carcinogenesis, should be evaluated.

METHODS:

MSC isolated from human umbilical cord blood (UCB) and adipose tissue (AD) were transplanted in a mouse cancer metastasis model. The effects of MSC on tumor growth and metastasis were analyzed. The effects of transplantation of MSC into the mouse model at very early stage carcinogenesis were also evaluated.

RESULTS:

Human MSC reduced lung metastasis and inhibited the growth of human breast cancer cells by inducing apoptosis. In addition, transplantation of both UCB and AD MSC into a cancer model with no detectable clinical symptoms did not appear to promote tumor growth or metastasis.

CONCLUSIONS:

We evaluated the effect of MSC derived from human UCB and AD tissue in a tumor model. Our findings may help to elucidate the interaction between cancer cells and MSC, as well as the application of MSC to clinical trials.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Transplante de Células-Tronco Mesenquimais / Células-Tronco Mesenquimais / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Cytotherapy Assunto da revista: TERAPEUTICA Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Transplante de Células-Tronco Mesenquimais / Células-Tronco Mesenquimais / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Cytotherapy Assunto da revista: TERAPEUTICA Ano de publicação: 2009 Tipo de documento: Article