Signaling networks associated with BCR-ABL-dependent transformation.
Cancer Control
; 16(2): 100-7, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19337196
ABSTRACT
BACKGROUND:
The fusion protein BCR-ABL results in constitutive tyrosine kinase activity. It also affects downstream targets as well as the subcellular location of the normally tightly regulated Abl tyrosine kinase.METHODS:
The authors review the current knowledge concerning the signaling networks associated with BCR-ABL-dependent transformation.RESULTS:
Although BCR-ABL is considered a single genetic change, the dysregulated tyrosine kinase activates a network of signals that contributes to cytokine-independent growth, resistance to apoptosis, and genetic instability.CONCLUSIONS:
The effectiveness of BCR-ABL-dependent transformation of hematopoietic stem cells is due not to a single pathway but rather to the culmination of a network of signaling pathways.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Transformação Celular Neoplásica
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Control
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos