Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE.
Bioorg Med Chem Lett
; 19(10): 2654-60, 2009 May 15.
Article
em En
| MEDLINE
| ID: mdl-19375914
ABSTRACT
A series of N-((2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-(3-methoxybenzylamino)-butan-2-yl)benzamides has been synthesized as BACE inhibitors. A variety of P2 and P3 substituents has been explored, and these efforts have culminated in the identification of several 1,3,5-trisubstituted phenylcarboxyamides with potent BACE inhibitory activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteases
/
Benzamidas
/
Secretases da Proteína Precursora do Amiloide
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos