Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages.
Leuk Res
; 34(1): 63-8, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19406473
ABSTRACT
Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change after 13q deletion. It never occurred as a sole abnormality and was associated with other changes (6q deletion; 1p gain). The region of 2p gain frequently included two oncogenes, REL and MYCN. All patients with gain of REL were unmutated for IGHV (p=0.03). Gain of MYCN was associated with increased mRNA expression (p=0.005), suggesting a pathogenic role for MYCN. Gain of 2p appears to be a marker of progression and may contribute to the poor prognosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 2
/
Leucemia Linfocítica Crônica de Células B
/
Aberrações Cromossômicas
Limite:
Humans
Idioma:
En
Revista:
Leuk Res
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
França