[The two faces of autophagy in the nervous system]. / Les deux visages de l'autophagie dans le système nerveux.
Med Sci (Paris)
; 25(4): 383-90, 2009 Apr.
Article
em Fr
| MEDLINE
| ID: mdl-19409191
ABSTRACT
Autophagy is a cellular mechanism for degrading proteins and organelles. It was first described as a physiological process essential for maintaining homeostasis and cell survival, but understanding its role in conditions of stress has been complicated by the recognition of a new type of cell death ("type 2") characterized by deleterious autophagic activity. This paradox is important in the central nervous system where the activation of autophagy seems to be protective in certain neurodegenerative diseases but deleterious in cerebral ischemia. The development of new therapeutic strategies based on the manipulation of autophagy will need to take into account these opposing roles of autophagy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Isquemia Encefálica
/
Doenças Neurodegenerativas
/
Fenômenos Fisiológicos do Sistema Nervoso
Limite:
Animals
/
Humans
Idioma:
Fr
Revista:
Med Sci (Paris)
Assunto da revista:
MEDICINA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Suíça