Modeling of glycolytic wave propagation in an open spatial reactor with inhomogeneous substrate influx.
Biosystems
; 97(2): 127-33, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19409445
ABSTRACT
The spatio-temporal dynamics of traveling waves in glycolysis as it occurs in yeast extract have been studied, both theoretically and experimentally. We describe this phenomenon with the distributed Selkov model that accounts for the reactions of phosphofructokinase, which is a key enzyme of the glycolytic reaction cascade. To describe the experimentally observed phase waves in an open spatial reactor we introduce a non-homogeneous flux of substrate in the model. The experimental observation that waves can change their direction of propagation during the experiment is considered in the model. The mechanism for such a change in wave direction is discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biofísica
/
Glicólise
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Biosystems
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Alemanha