Expression of metallothionein and p53 antigens are correlated in oral squamous cell carcinoma.
Anticancer Res
; 29(4): 1189-93, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19414363
ABSTRACT
BACKGROUND:
Metallothionein and p53 proteins have been associated with tumoral evolution and resistance against therapy. Experimentally, the former may modulate the activity of tumor suppressor protein through zinc exchange. However, there is no information on the relationship of these proteins in oral cancer. PATIENTS ANDMETHODS:
Immunohistochemical detection of metallothionein and p53 antigens was performed in 100 oral squamous cell carcinomas. Results were compared to evaluate possible relationships between them and the disease-specific survival.RESULTS:
Mean cellular indexes of positivity were 66.5% and 52.5% for metallothionein and p53, respectively, and a positive correlation was found between them. Frequent nuclear metallothionein immunolocalization was associated to increased p53 expression. Concomitant overexpression of both antigens predicted shorter survival for patients with advanced disease.CONCLUSION:
These results corroborate the speculated association between metallothionein and p53 and suggest that simultaneous assessment of these proteins may be useful to evaluate aggressiveness of oral cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Biomarcadores Tumorais
/
Proteína Supressora de Tumor p53
/
Metalotioneína
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Brasil