Your browser doesn't support javascript.
loading
Acute phase protein concentrations in retired racing Greyhounds.
Couto, C Guillermo; Cerón, José J; Parra, M D; Martínez-Subiela, Silvi; Iazbik, M Cristina; Lazbik, M Cristina.
Afiliação
  • Couto CG; Department of Veterinary Clinical Sciences, College of Veterinary Medicine and The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. couto.1@osu.edu
Vet Clin Pathol ; 38(2): 219-23, 2009 Jun.
Article em En | MEDLINE | ID: mdl-19470149
BACKGROUND: Retired racing Greyhounds are popular as pets. Greyhounds have several differences in physiological values compared with other breeds, including lower serum alpha- and beta-globulin concentrations. We hypothesized that lower acute phase protein (APP) concentrations could contribute to lower alpha- and beta-globulin concentrations in this breed. OBJECTIVES: The purpose of this study was to compare serum concentrations of several APPs in Greyhounds with those of other dog breeds. METHODS: We measured the serum concentrations of C-reactive protein (CRP), haptoglobin (Hp), acid-soluble glycoprotein (ASG), ceruloplasmin (CP), and serum amyloid A (SAA) in 15 clinically healthy retired racing Greyhounds and 11 age- and gender-matched healthy nonGreyhound controls using previously validated methods. Results were compared by Student's t-tests. RESULTS: The concentration of Hp by both colorimetric and immunoturbidimetric methods was significantly lower in Greyhounds than in nonGreyhound dogs (P=.0009 and .019, respectively). The concentration of ASG was also significantly (P=.007) lower in Greyhounds, but CRP and CP concentrations were not significantly different between groups. SAA concentration was below the detection limit of the method in all dogs. CONCLUSIONS: The low serum concentrations of Hp and ASG should be taken into consideration when interpreting APP results in Greyhounds. Because both Hp and some ASG migrate in the alpha-globulin fraction, these results may explain the low alpha-globulin concentrations in Greyhounds.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Fase Aguda / Cães Limite: Animals Idioma: En Revista: Vet Clin Pathol Assunto da revista: MEDICINA VETERINARIA / PATOLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Fase Aguda / Cães Limite: Animals Idioma: En Revista: Vet Clin Pathol Assunto da revista: MEDICINA VETERINARIA / PATOLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Estados Unidos