[Evaluation of insulin resistance in type 1 diabetes with euglycemic-hyperinsulinemic clamp].
Zhonghua Nei Ke Za Zhi
; 48(1): 10-2, 2009 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-19484969
ABSTRACT
OBJECTIVE:
To investigate insulin resistance in type 1 diabetes (T1DM) with euglycemic-hyperinsulinemic clamp.METHODS:
Eight cases of newly diagnosed T1DM and 8 cases of newly diagnosed type 2 diabetes (T2DM) were selected. Their insulin sensitivity index (ISI) was evaluated with euglycemic-hyperinsulinemic clamp after 2 week insulin intensive treatment and compared with that of 10 healthy volunteers (normal control group, NC group).RESULTS:
Age, BMI, fasting insulin (FIns), fasting C-peptide in the T1DM group were significantly lower than those in the NC group, while waist-to-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), TC, TG, LDL-C, HDL-C were not significantly different between the T1DM and NC groups. Age, BMI, WHR, FIns, fasting C-peptide, SBP, TC, TG in the T1DM group were significantly lower than those in the T2DM group. The ISI of the NC, T1DM and T2DM groups were 12. 83 +/- 1.09, 9.95 +/-0.50, 3.80 +/- 0.20, respectively. There was significant difference among the three groups (P < 0.05).CONCLUSION:
The ISI in T1DM was significantly lower than that in NC group, but higher than that in T2DM.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Resistência à Insulina
/
Técnica Clamp de Glucose
/
Diabetes Mellitus Tipo 1
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Nei Ke Za Zhi
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China