Immune senescence and brain aging: can rejuvenation of immunity reverse memory loss?
Trends Neurosci
; 32(7): 367-75, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19520437
ABSTRACT
The factors that determine brain aging remain a mystery. Do brain aging and memory loss reflect processes occurring only within the brain? Here, we present a novel view, linking aging of adaptive immunity to brain senescence and specifically to spatial memory deterioration. Inborn immune deficiency, in addition to sudden imposition of immune malfunction in young animals, results in cognitive impairment. As a corollary, immune restoration at adulthood or in the elderly results in a reversal of memory loss. These results, together with the known deterioration of adaptive immunity in the elderly, suggest that memory loss does not solely reflect chronological age; rather, it is an outcome of the gap between an increasing demand for maintenance (age-related risk-factor accumulation) and the reduced ability of the immune system to meet these needs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rejuvenescimento
/
Encéfalo
/
Envelhecimento
/
Imunidade Adaptativa
/
Transtornos da Memória
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Neurosci
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Israel