Congenital heart block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases.
J Rheumatol
; 36(8): 1744-8, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19567621
ABSTRACT
OBJECTIVE:
To study anti-Ro/La-negative congenital heart block (CHB).METHODS:
Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods.RESULTS:
There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers.CONCLUSION:
Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Ribonucleoproteínas
/
Autoantígenos
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Anticorpos Antinucleares
/
Bloqueio Atrioventricular
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Female
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Humans
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Male
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Newborn
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Pregnancy
Idioma:
En
Revista:
J Rheumatol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Itália