Serotonin transporter genotype, morning cortisol and subsequent depression in adolescents.
Br J Psychiatry
; 195(1): 39-45, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19567894
ABSTRACT
BACKGROUND:
The short (s) allele of the serotonin transporter gene promoter (5-HTTLPR) may be associated with exposure to social adversities and the subsequent onset of depressive illness in adulthood.AIMS:
To test in adolescents at high risk for depression whether the short 's' allele is associated with levels of morning cortisol and the subsequent onset of a depressive episode.METHOD:
High-risk adolescents (n = 403) were genotyped for 5-HTTLPR. Salivary samples were obtained on four consecutive school days within 1 h of waking from 393 (97.5%) individuals and 367 (91%) underwent a mental state reassessment at 12 months.RESULTS:
Multilevel analysis revealed higher levels of salivary cortisol in short allele carriers (s/s>s/l>l/l). A subsequent episode of depression was increased in those with higher cortisol and the 's' allele, and independently by depressive symptoms at entry, in both genders.CONCLUSIONS:
The short allele of 5-HTTLPR may moderate the association between morning cortisol and the subsequent onset of a depressive episode.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidrocortisona
/
Predisposição Genética para Doença
/
Transtorno Depressivo
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Proteínas da Membrana Plasmática de Transporte de Serotonina
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Br J Psychiatry
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Reino Unido