19F nuclear magnetic resonance spectroscopy of neuroleptics: the first in vivo pharmacokinetics of trifluoperazine in the rat brain and the first in vivo spectrum of fluphenazine in the human brain.
Biol Psychiatry
; 30(7): 656-62, 1991 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-1958765
ABSTRACT
In vivo 19F nuclear magnetic resonance (19F-NMR) spectroscopy measurements of trifluorinated neuroleptics (fluphenazine--FL and trifluoperazine--TFP) were made in rat brain as well as in human brain. Animal studies were performed at 4.7 Tesla. Using rats that have been treated with FL over a period of 3 weeks, a NMR signal could be detected within 8-15 min. Following a single intravenous injection of TFP, brain levels could be monitored with a time resolution of 30 min. The first 19F-NMR examination of a patient was made at 3.0 Tesla 1 day after injection of FL decanoate (37.5 mg) in the course of which a signal could be detected within 30 min. It is expected that 19F-NMR will become an important tool in psychopharmacological research.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trifluoperazina
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Encéfalo
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Espectroscopia de Ressonância Magnética
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Flufenazina
Limite:
Adult
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Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Biol Psychiatry
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Alemanha