Antibody limits in vivo murid herpesvirus-4 replication by IgG Fc receptor-dependent functions.
J Gen Virol
; 90(Pt 11): 2592-2603, 2009 Nov.
Article
em En
| MEDLINE
| ID: mdl-19625459
ABSTRACT
Antibody is an important antiviral defence. However, it is considered to do little against human gamma-herpesviruses, which establish predominantly latent infections regulated by T cells. One limitation on analysing these infections has been that latency is already well-established at clinical presentation; early infection may still be accessible to antibody. Here, using murid herpesvirus-4 (MuHV-4), we tested the impact of adoptively transferred antibody on early gamma-herpesvirus infection. Immune sera and neutralizing and non-neutralizing monoclonal antibodies (mAbs) all reduced acute lytic MuHV-4 replication. The reductions, even by neutralizing mAbs, were largely or completely dependent on host IgG Fc receptors. Therefore, passive antibody can blunt acute gamma-herpesvirus lytic infection, and does this principally by IgG Fc-dependent functions rather than by neutralization.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
/
Imunoglobulina G
/
Receptores Fc
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Rhadinovirus
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Anticorpos Antivirais
Limite:
Animals
Idioma:
En
Revista:
J Gen Virol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Reino Unido