Delta 9-tetrahydrocannabinol enhances presynaptic dopamine efflux in medial prefrontal cortex.
Eur J Pharmacol
; 190(1-2): 259-62, 1990 Nov 06.
Article
em En
| MEDLINE
| ID: mdl-1963849
ABSTRACT
Acute administration of 1.0-2.0 mg/kg delta 9-tetrahydrocannabinol (delta 9-THC) increased presynaptic dopamine (DA) efflux in the medial prefrontal cortex of rats, as measured by intracerebral microdialysis in awake, behaving rats. These data are congruent with suggestions that (1) marijuana's euphorigenic effects and abuse potential may be related to augmentation of presynaptic DA mechanisms, and (2) the medial prefrontal cortex may be an important site of action for drugs of abuse in general and for delta 9-THC in particular.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Dronabinol
/
Dopamina
/
Córtex Cerebral
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1990
Tipo de documento:
Article