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A network-QSAR model for prediction of genetic-component biomarkers in human colorectal cancer.
Vilar, Santiago; González-Díaz, Humberto; Santana, Lourdes; Uriarte, Eugenio.
Afiliação
  • Vilar S; Department of Organic Chemistry, Faculty of Pharmacy, and Unit of Bioinformatics and Connectivity Analysis of Systems (UBICAS), Institute of Industrial Pharmacy, University of Santiago de Compostela, Santiago de Compostela 15782, Spain.
J Theor Biol ; 261(3): 449-58, 2009 Dec 07.
Article em En | MEDLINE | ID: mdl-19654012
ABSTRACT
The combination of the network theory and the calculation of topological indices (TIs) allow establishing relationships between the molecular structure of large molecules like the genes and proteins and their properties at a biological level. This type of models can be considered quantitative structure-activity relationships (QSAR) for biopolymers. In the present work a QSAR model is reported for proteins, related to human colorectal cancer (HCC) and codified by different genes that have been identified experimentally by Sjöblom et al. [2006. The consensus coding sequences of human breast and colorectal cancers. Science 314, 268-274] among more than 10000 human genes. The 69 proteins related to human colorectal cancer (HCCp) and a control group of 200 proteins not related to HCC (no-HCCp) were represented through an HP Lattice type Network. Starting from the generated graphs we calculate a set of descriptors of electrostatic potential type (xi(k)) that allow to establish, through a linear discriminant analysis (LDA), a QSAR model of relatively high percentage of good classification (higher than 80%) to differentiate between HCCp and no-HCCp proteins. The purpose of this study is helping to predict the possible implication of a certain gene and/or protein (biomarker) in the colorectal cancer. Different procedures of validation of the obtained model have been carried out in order to corroborate its stability, including cross-validation series (CV) and evaluation of an additional series of 200 no-HCCp. This biostatistic methodology could be applied to predict human colorectal cancer biomarkers and to understand much better the biological aspects of this disease.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Biomarcadores Tumorais / Relação Quantitativa Estrutura-Atividade / Proteínas de Neoplasias Tipo de estudo: Diagnostic_studies / Health_economic_evaluation / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Theor Biol Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Biomarcadores Tumorais / Relação Quantitativa Estrutura-Atividade / Proteínas de Neoplasias Tipo de estudo: Diagnostic_studies / Health_economic_evaluation / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Theor Biol Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Espanha