Murine gammaherpesvirus 68 infection of gamma interferon-deficient mice on a BALB/c background results in acute lethal pneumonia that is dependent on specific viral genes.
J Virol
; 83(21): 11397-401, 2009 Nov.
Article
em En
| MEDLINE
| ID: mdl-19710134
Gamma interferon (IFN-gamma) is critical for the control of chronic infection with murine gammaherpesvirus 68 (gammaHV68). Current data indicate that IFN-gamma has a lesser role in the control of acute replication of gammaHV68. Here, we show that IFN-gamma-deficient mice on the BALB/c genetic background poorly control acute viral replication and succumb to early death by acute pneumonia. Notably, this acute, lethal pneumonia was dependent not only on the viral dose, but also on specific viral genes including the viral cyclin gene, previously identified to be important in promoting optimal chronic infection and reactivation from latency.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumonia
/
Interferon gama
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Gammaherpesvirinae
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Infecções por Herpesviridae
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Genes Virais
Limite:
Animals
Idioma:
En
Revista:
J Virol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos