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The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) sigma factor protein family.
Staron, Anna; Sofia, Heidi J; Dietrich, Sascha; Ulrich, Luke E; Liesegang, Heiko; Mascher, Thorsten.
Afiliação
  • Staron A; KIT Research Group 11-1, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Mol Microbiol ; 74(3): 557-81, 2009 Nov.
Article em En | MEDLINE | ID: mdl-19737356
The ability of a bacterial cell to monitor and adaptively respond to its environment is crucial for survival. After one- and two-component systems, extracytoplasmic function (ECF) sigma factors - the largest group of alternative sigma factors - represent the third fundamental mechanism of bacterial signal transduction, with about six such regulators on average per bacterial genome. Together with their cognate anti-sigma factors, they represent a highly modular design that primarily facilitates transmembrane signal transduction. A comprehensive analysis of the ECF sigma factor protein family identified more than 40 distinct major groups of ECF sigma factors. The functional relevance of this classification is supported by the sequence similarity and domain architecture of cognate anti-sigma factors, genomic context conservation, and potential target promoter motifs. Moreover, this phylogenetic analysis revealed unique features indicating novel mechanisms of ECF-mediated signal transduction. This classification, together with the web tool ECFfinder and the information stored in the Microbial Signal Transduction (MiST) database, provides a comprehensive resource for the analysis of ECF sigma factor-dependent gene regulation.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator sigma / Bactérias / Proteínas de Bactérias / Transdução de Sinais Tipo de estudo: Prognostic_studies Idioma: En Revista: Mol Microbiol Assunto da revista: BIOLOGIA MOLECULAR / MICROBIOLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator sigma / Bactérias / Proteínas de Bactérias / Transdução de Sinais Tipo de estudo: Prognostic_studies Idioma: En Revista: Mol Microbiol Assunto da revista: BIOLOGIA MOLECULAR / MICROBIOLOGIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Alemanha