Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin.
Clin Vaccine Immunol
; 16(11): 1696-9, 2009 Nov.
Article
em En
| MEDLINE
| ID: mdl-19759250
ABSTRACT
Recombinant Sindbis viruses were engineered to express alternative forms of the protective antigen (PA) of Bacillus anthracis. The recombinant viruses induced PA-specific immunoglobulin G and neutralizing antibodies in Swiss Webster mice. Vaccination with the recombinant viruses induced immunity that offered some protection from a lethal Ames strain spore challenge and synergized the protective effects of ciprofloxacin.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sindbis virus
/
Bacillus anthracis
/
Toxinas Bacterianas
/
Ciprofloxacina
/
Vacinas contra Antraz
/
Vetores Genéticos
/
Antraz
/
Antibacterianos
/
Antígenos de Bactérias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Vaccine Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos