Evaluation of triazolamers as active site inhibitors of HIV-1 protease.
Bioorg Med Chem Lett
; 19(21): 6023-6, 2009 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-19800230
Proteases typically recognize their peptide substrates in extended conformations. General approaches for designing protease inhibitors often consist of peptidomimetics that feature this conformation. Herein we discuss a combination of computational and experimental studies to evaluate the potential of triazole-linked beta-strand mimetics as inhibitors of HIV-1 protease activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triazóis
/
Protease de HIV
/
Inibidores da Protease de HIV
/
Fármacos Anti-HIV
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos