[The comparison of the expansion of polyps according to the Ki-67 and computed tomography scores]. / Polip yayginliginin Ki-67 ve bilgisayarli tomografi skorlarina göre karsilastirilmasi.

ABSTRACT

OBJECTIVES: The disease extention in nasal polyps was compared by using the mitotic activity rates and the computed tomography scores. PATIENTS AND METHODS: This study was conducted on 19 nasal polyposis patients (8 males, 11 females; mean age 40.0+/-13.7 years; range 20 to 63 years). The preoperative computed tomography records of the patients were evaluated according to the Lund-Mackay grading system. The polyp tissues of the same patients were stained with the Ki-67 antigen for immunohistochemical evaluation. The correlation between the radiologic results and the Ki-67 values was compared by means of the Spearman's correlation test. RESULTS: The mean computed tomography score was observed as 14.3+/-4.7 (range 7-24). The mean Ki-67 score resulting from the immunohistochemical staining was calculated as 24.3+/-18.5 (range 3.3-73.5%). A significant correlation was determined between the Ki-67 values and the computed tomography scores. ("Spearman's" correlation factor 0.677; p<0.001). CONCLUSION: As the mitotic activity rate of nasal polyps increases, both the volume of the polyps and the computed tomography scores increase as a result of the blockage of the sinus ostiums by the increased polyp volume.