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The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors.
Town, Liam; McGlinn, Edwina; Fiorenza, Salvatore; Metzis, Vicki; Butterfield, Natalie C; Richman, Joy M; Wicking, Carol.
Afiliação
  • Town L; The University of Queensland, Institute for Molecular Bioscience, Queensland, Australia.
Dev Dyn ; 238(12): 3175-84, 2009 Dec.
Article em En | MEDLINE | ID: mdl-19877269
Pitrm1 is a zinc metalloendopeptidase that has been implicated in Alzheimer's disease and mitochondrial peptide degradation, but to date no major role in embryonic development has been documented. In a screen for genes regulated by hedgehog signaling in the mouse limb, we showed that expression of Pitrm1 is upregulated in response to loss of the Gli3 transcription factor. Here we confirm spatial changes in Pitrm1 expression in the Gli3 mutant mouse limb and examine Pitrm1 expression in Shh null and Ptch1 conditional deletion mouse mutants. In wild-type mice, Pitrm1 is expressed in a number of developing tissues known to be patterned by Sonic hedgehog, including the limbs, face, cortex, hippocampus, cerebellum, tectum, sub-mandibular gland, lung, genital tubercle, hair follicles, and the enamel knot of the teeth. Additionally, Pitrm1 is expressed in Pax3-expressing myoblast progenitors in the limb, the dermomyotome, and developing muscles of the face and torso.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco / Metaloendopeptidases / Músculo Esquelético / Extremidades / Proteínas Hedgehog Limite: Animals Idioma: En Revista: Dev Dyn Assunto da revista: ANATOMIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Austrália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco / Metaloendopeptidases / Músculo Esquelético / Extremidades / Proteínas Hedgehog Limite: Animals Idioma: En Revista: Dev Dyn Assunto da revista: ANATOMIA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Austrália