Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor.
Bioorg Med Chem Lett
; 20(1): 276-9, 2010 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-19945872
ABSTRACT
AP18 1 was recently disclosed as an antagonist of the TRPA1 receptor by the research group of Patapoutian. However, no detailed structure-activity relationships around 1 have been disclosed. Thus, a small number of oximes related to AP18 were examined in order to characterize the determinants of TRPA1 activity. Congeners of AP18 were found to possess both agonist and antagonist activity, suggesting that AP18 may behave as a covalent antagonist of the TRPA1 ion-channel.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Canais de Potencial de Receptor Transitório
/
Proteínas do Tecido Nervoso
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos