Parameter estimation methodology in a model of hydrophobic drug release from a polymer coating.
J Control Release
; 142(3): 474-82, 2010 Mar 19.
Article
em En
| MEDLINE
| ID: mdl-19958804
ABSTRACT
The TAXUS Express coronary artery stent delivers a sustained dose of a hydrophobic drug (paclitaxel) from a hydrophobic polymer coating (poly(styrene-isobutylene-styrene), SIBS). It is known that particles of concentrated drug are dispersed throughout the polymer coating, however, the mechanism by which drug exits the polymer matrix is not fully characterized. In this work, mathematical models were applied to in vitro controlled release data obtained from 8.8, 25 and 35% loadings of drug in polymer. Models that accounted for release by different mechanisms were tested. It was observed that Fickian diffusion, dissolution and osmotic gradient models were capable of fitting the data equally well. It was also possible to fit the data with a variety of parameter combinations, even if the values of some parameters were unlikely. We use the example of Paclitaxel release from the SIBS matrix to discuss important considerations in fitting controlled release data with mechanistic models.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estirenos
/
Portadores de Fármacos
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Paclitaxel
/
Materiais Revestidos Biocompatíveis
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Stents Farmacológicos
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Modelos Biológicos
Limite:
Humans
Idioma:
En
Revista:
J Control Release
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos