Uveal melanoma, hormonal and reproductive factors in women.
Cancer Res
; 51(5): 1370-2, 1991 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-1997174
In a case-control study, we explored a potential association between uveal melanoma and reproductive factors in women. Responses from telephone interviews of 186 women diagnosed with uveal melanoma were compared with responses of 423 women without this disease. All women resided in 11 U.S. western states. We observed a decreased risk of uveal melanoma for women who had ever been pregnant [relative risk (RR) = 0.60, 95% confidence interval (CI) = 0.37 -0.95], with an increase in this protective effect with more live births after adjustment for age, menopausal status, eye color, and skin sensitivity to the sun (1-2 births, RR = 0.47,95% CI 0.29-0.78; 3-4 births, RR = 0.38, 95% CI = 0.22-0.64; 5 or more births, RR = 0.33, 95% CI = 0.15-0.71). The largest effect was observed between nulliparous and parous women. No other reproductive factors, including use of oral contraceptives or postmenopausal estrogens, were shown to be related to risk for uveal melanoma. We conclude that most reproductive factors in this population play little or no role in the etiology of uveal melanoma. The association with number of live births must be confirmed in other studies to assure that it is unrelated to confounding factors not measured in this study.
Palavras-chave
Americas; Biology; Cancer--etiology; Case Control Studies; Contraception; Contraceptive Methods; Control Groups; Data Analysis; Data Collection; Demographic Factors; Developed Countries; Diseases; Family Planning; Fertility; Fertility Measurements; Neoplasms; North America; Northern America; Ophthalmological Effects; Oral Contraceptives; Parity; Physiology; Population; Population Dynamics; Pregnancy History; Reproduction; Research Methodology; Risk Factors; Studies; Time Factors; United States
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reprodução
/
Neoplasias Uveais
/
Melanoma
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
/
Pregnancy
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1991
Tipo de documento:
Article