The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors.
Bioorg Med Chem Lett
; 20(3): 1189-93, 2010 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-20022498
ABSTRACT
A novel series of TNF-alpha convertase (TACE) inhibitors which are non-hydroxamate have been discovered. These compounds are bis-amides of L-tartaric acid (tartrate) and coordinate to the active site zinc in a tridentate manner. They are selective for TACE over other MMP's. We report the first X-ray crystal structure for a tartrate-based TACE inhibitor.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteases
/
Tartaratos
/
Fator de Necrose Tumoral alfa
/
Proteínas ADAM
/
Descoberta de Drogas
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos