Your browser doesn't support javascript.
loading
The continuum of growth hormone-IGF-I axis defects causing short stature: diagnostic and therapeutic challenges.
Savage, Martin O; Burren, Christine P; Rosenfeld, Ron G.
Afiliação
  • Savage MO; Department of Endocrinology, William Harvey Research Institute, Barts and the Royal London School of Medicine & Dentistry, London, UK. m.o.savage@qmul.ac.uk
Clin Endocrinol (Oxf) ; 72(6): 721-8, 2010 Jun.
Article em En | MEDLINE | ID: mdl-20050859
The growth hormone (GH)-IGF-I axis is essential for normal foetal and childhood growth. Defects at different sites in the axis frequently result in short stature which may compromise adult height. We describe a continuum of clinically relevant abnormalities from GH deficiency through to GH resistance and discuss the implementation and interpretation of investigations. We consider appropriate therapy for patients with abnormal auxology and subnormal adult height prognosis, highlighting new data to clarify therapeutic choices leading to optimal clinical outcome.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estatura / Fator de Crescimento Insulin-Like I / Hormônio do Crescimento Humano / Transtornos do Crescimento Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Humans Idioma: En Revista: Clin Endocrinol (Oxf) Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estatura / Fator de Crescimento Insulin-Like I / Hormônio do Crescimento Humano / Transtornos do Crescimento Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Humans Idioma: En Revista: Clin Endocrinol (Oxf) Ano de publicação: 2010 Tipo de documento: Article