The continuum of growth hormone-IGF-I axis defects causing short stature: diagnostic and therapeutic challenges.
Clin Endocrinol (Oxf)
; 72(6): 721-8, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20050859
The growth hormone (GH)-IGF-I axis is essential for normal foetal and childhood growth. Defects at different sites in the axis frequently result in short stature which may compromise adult height. We describe a continuum of clinically relevant abnormalities from GH deficiency through to GH resistance and discuss the implementation and interpretation of investigations. We consider appropriate therapy for patients with abnormal auxology and subnormal adult height prognosis, highlighting new data to clarify therapeutic choices leading to optimal clinical outcome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estatura
/
Fator de Crescimento Insulin-Like I
/
Hormônio do Crescimento Humano
/
Transtornos do Crescimento
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Clin Endocrinol (Oxf)
Ano de publicação:
2010
Tipo de documento:
Article