New adjuvants to enhance anticoagulant activity of warfarin.

Stromich, Jeremiah J; Weber, Ashley K; Mirzaei, Yousef R; Caldwell, Michael D; Lewis, David E

Stromich, Jeremiah J; Weber, Ashley K; Mirzaei, Yousef R; Caldwell, Michael D; Lewis, David E.

Afiliação

Stromich JJ; Department of Chemistry, University of Wisconsin-Eau Claire, Eau Claire, WI 54702, USA.

Bioorg Med Chem Lett ; 20(6): 1928-32, 2010 Mar 15.

Article em En | MEDLINE | ID: mdl-20167480

ABSTRACT

ABSTRACT

New adjuvants of warfarin anticoagulant activity have been developed. These compounds, which are 1,4-methano-1,2,3,4-tetrahydroanthracene-9,10-diol derivatives, act synergistically with warfarin to potentiate its anticoagulant effect. None of the compounds tested is an effective oral anticoagulant in the absence of warfarin.

Assuntos

Anticoagulantes/farmacologia; Varfarina/farmacologia; Animais; Sinergismo Farmacológico; Masculino; Ratos; Ratos Sprague-Dawley

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Varfarina / Anticoagulantes Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Estados Unidos

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