Palladium-catalyzed amination of aromatic C-H bonds with oxime esters.
J Am Chem Soc
; 132(11): 3676-7, 2010 Mar 24.
Article
em En
| MEDLINE
| ID: mdl-20187645
ABSTRACT
We report a conceptually new approach to the direct amination of aromatic C-H bonds. In this process, an oxime ester function reacts with an aromatic C-H bond under redox-neutral conditions to form, in the case studied, an indole product. These reactions occur with relatively low catalyst loading (1 mol %) by a mechanism that appears to involve an unusual initial oxidative addition of an N-O bond to a Pd(0) species. The Pd(II) complex from oxidative addition of the N-X bond has been isolated for the first time, and evidence for the intermediacy of such oxidative addition products in the catalytic reaction has been gained.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Paládio
/
Carbono
/
Ésteres
/
Hidrocarbonetos Aromáticos
/
Hidrogênio
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos